How many of the following statements about craniates is (are) correct? 1. Craniates are more highly cephalized than are noncraniates. 2. Craniates’ genomic evolution includes duplication of clusters of genes that code for transcription factors. 3. The craniate clade is synonymous with the vertebrate clade. 4. Pharyngeal slits that play important roles in gas exchange originated in craniates. 5. The two-chambered heart originated with the early craniates.

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